Causal analysis of different mental disorders and ischemic stroke： A Mendelian randomization study
10.19845/j.cnki.zfysjjbzz.2026.0027
- VernacularTitle:不同精神障碍与缺血性脑卒中的因果分析：孟德尔随机化研究
- Author:
Keke HOU
1
;
Mengmeng HOU
2
Author Information
1. Jiading Hospital of Traditional Chinese Medicine， Shanghai 201800， China
2. The First Affiliated Hospital of Henan University of Science and Technology，Luoyang 471003，China
- Publication Type:Journal Article
- Keywords:
Mental disorders;
Ischemic stroke;
Mendelian randomization;
Causal analysis
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):150-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal effect of major depression， schizophrenia， bipolar affective disorder， and insomnia on the risk of ischemic stroke using the two-sample Mendelian randomization method. Methods Eligible single nucleotide polymorphism data of four distinct mental disorders and stroke were obtained from genome-wide association studies. The random effects IVW method， the MR-Egger method， and the weighted median method were used to perform two-sample Mendelian randomization analyses， and heterogeneity test， horizontal pleiotropy analysis， and sensitivity analysis were also performed. Results IVW results showed a positive causal effect between major depression （OR=1.226，95%CI 1.046-1.436， PIVW=0.012， PFDR=0.047） with the risk of ischemic stroke. For heterogeneity test， the Cochran’s Q test using the IVW method showed a Q value of 44.198（P=0.379） for major depression. In the pleiotropy test， the intercept of MR-Egger regression showed a P-value of 0.667， and the sensitivity analysis yielded robust results， indicating that there was no significant heterogeneity or pleiotropy. These findings suggested that major depression was a risk factor for ischemic stroke. Schizophrenia （OR=1.005，95%CI 0.967‒1.045，PIVW=0.810，PFDR=0.810）， bipolar disorder （OR=0.946，95%CI 0.847‒1.055，PIVW=0.318，PFDR=0.424）， and insomnia （OR=0.773， 95%CI 0.483‒1.237，PIVW=0.283，PFDR=0.424） had no causal relationship with the onset of ischemic stroke. Conclusion There is a positive causal relationship between major depression and the risk of ischemic stroke， and screening and prevention for ischemic stroke should be enhanced for patients with major depression， so as to reduce their risk of developing ischemic stroke.
