Causal relationship between Parkinson disease and the risk of mental illness： A two-sample Mendelian randomization study
10.19845/j.cnki.zfysjjbzz.2026.0026
- VernacularTitle:帕金森病与精神疾病发生风险的因果关系：一项双样本孟德尔随机化研究
- Author:
Siyu WANG
1
;
Qingsong WANG
1
Author Information
1. Department of Rehabilitation Medicine，Xiangyang First People’s Hospital，Hubei Medical College，Xiangyang 441000，China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Parkinson disease;
Depression;
Sleep disorders;
Anxiety
- MeSH:
Depression;
Anxiety
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective Observational studies have shown an association between Parkinson disease （PD） and mental illness， but further studies are needed to explore the causal relationship between them. This study aims to investigate such causal relationship using the method of two-sample Mendelian randomization （MR）. Methods Related data were extracted from GWAS， and summary statistics associated with PD， depression， sleep disorders， and anxiety phenotype-variants were obtained. Single nucleotide polymorphisms （SNPs） for PD were selected as instrumental variables， and MR-PRESSO was used to exclude outliers. Inverse variance weighting was used as the main method to assess causal effect estimates， and MR Egger， weighted median， simple mode， and weighted mode were used to verify the robustness of the findings. A sensitivity analysis was used to validate the reliability of the results， including the Cochran Q test， the MR-Egger intercept test， funnel plots， and the leave-one-out method. Results A total of 21 SNPs associated with PD were identified. The MR analysis showed that PD had a causal relationship with depression （OR=0.974，95%CI 0.934‒1.015， P=0.210）， sleep disorders （OR=1.056， 95%CI 0.970-1.149， P=0.211）， and anxiety （OR=0.998， 95%CI 0.996‒1.001， P=0.118）， with no statistical significance. Different MR analyses and sensitivity analyses showed that PD did not directly contribute to the development of mental illness. Conclusion There is no direct causal relationship between PD and depression/sleep disorders/anxiety. In clinical practice， healthcare professionals should pay attention to the mental health of patients with PD. Randomized controlled studies should be conducted in the future to further validate the results of this study.
- Full text:2026060913571753374帕金森病与精神疾病发生风险的因果关系：一项双样本孟德尔随机化研究.pdf
