Cranial magnetic resonance imaging features and risk factors for seizures in patients with hepatolenticular degeneration and epilepsy
10.19845/j.cnki.zfysjjbzz.2026.0019
- VernacularTitle:肝豆状核变性合并癫痫患者头部MRI特征及癫痫发作危险因素分析
- Author:
Jing LIN
1
;
Xu'en YU
2
Author Information
1. Anhui University of Chinese Medicine， Hefei 230038，China
2. Anhui University of Chinese Medicine， Hefei 230038，China; Department of Neurology， Affiliated Hospital of Neurology Institute， Anhui University of Chinese Medicine， Hefei 230061，China
- Publication Type:Journal Article
- Keywords:
Hepatolenticular degeneration;
Epilepsy;
Cranial magnetic resonance imaging;
Putamen;
Frontal lobe
- MeSH:
Epilepsy, Frontal Lobe;
Putamen
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):110-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cranial magnetic resonance imaging （MRI） features of patients with hepatolenticular degeneration （also known as Wilson disease，WD） and epilepsy， and to identify the neuroimaging risk factors for seizures in WD patients. Methods A total of 69 WD patients with epilepsy who were hospitalized in Affiliated Hospital of Neurology Institute， Anhui University of Chinese Medicine， from January 2018 to November 2025 were enrolled as study group， while 80 WD patients without seizures， matched for sex and age， during the same period of time were randomly selected as control group. Cranial MRI findings were compared between the two groups. Results There were 69 WD patients （43 male patients and 26 female patients） in the study group， with a mean age of （29.46±8.58） years at the time of attending the hospital， and all these patients had abnormal electroencephalogram （EEG） findings. There were no significant differences between the two groups in age of onset，disease duration， WD subtype， and serum copper. Cranial MRI showed that the putamen was the most common site of brain injury （47 patients， 68.1%）， followed by the frontal lobe （40 patients，58.0%） and the parietal lobe （31 patients，44.9%）， and there was a significantly higher probability of epilepsy in patients with abnormal lesions in the frontal， temporal， or parietal lobes （P<0.05）. Conclusion While the putamen is the most common site of brain injury in WD patients with epilepsy， frontal or temporal lobe injuries are neuroimaging risk factors for seizures in such patients.
- Full text:2026060814412664879肝豆状核变性合并癫痫患者头部MRI特征及癫痫发作危险因素分析.pdf
