Identification of risk factors for cardiac magnetic resonance imaging abnormalities in hepatolenticular degeneration and screening of indicators for early diagnosis
10.19845/j.cnki.zfysjjbzz.2026.0017
- VernacularTitle:肝豆状核变性患者心脏MRI异常的危险因素识别及早期诊断价值指标筛选
- Author:
Juan WANG
1
;
Renmin YANG
2
Author Information
1. 合肥市第二人民医院神经内科，安徽 合肥 230001
2. 安徽中医药大学神经病学研究所附属医院神经内科，安徽 合肥 230061
- Publication Type:Journal Article
- Keywords:
Hepatolenticular degeneration;
Cardiac magnetic resonance imaging;
Serum copper;
Risk factors;
Combined indicators
- From:
Journal of Apoplexy and Nervous Diseases
2026;43(2):99-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for abnormal cardiac function in patients with hepatolenticular degeneration （also known as Wilson disease ，WD） using cardiac magnetic resonance imaging （CMR）， and to identify indicators with a value for early diagnosis. Methods Patients diagnosed with WD were randomly selected to undergo CMR examination， and based on CMR findings， they were divided into abnormal group and normal group. A univariate analysis was used to obtain potential risk factors， then a multivariate logistic regression analysis was performed for variables with a significant difference， and finally the receiver operating characteristic （ROC） curve analysis was performed for the independent risk factors identified. Results A total of 42 WD patients were enrolled， with 21 in the abnormal CMR group and 21 in the normal CMR group. Compared with the normal CMR group， the abnormal CMR group had a significantly higher age and significantly higher levels of total bilirubin， serum copper， and peak 24-hour urinary copper during treatment. The multivariate Logistic regression analysis showed that white blood cell count （WBC） （OR=2.927， 95%CI 1.127‒7.839， P=0.028）， serum copper（OR=3.822， 95%CI 1.108‒13.178， P=0.034）， and type Ⅳ collagen （OR=1.097， 95%CI 1.011‒1.191，P=0.027） were independent risk factors for CMR abnormalities in WD patients. The ROC curve analysis showed that among the above three indicators used alone， serum copper had the highest diagnostic value with an area under the ROC curve （AUC） of 0.713， followed by WBC（AUC=0.651） and type Ⅳ collagen （AUC=0.644）， and the combination of these three indicators had significantly higher diagnostic efficacy （AUC=0.869）. Conclusion Serum copper is the single indicator with the highest diagnostic efficacy for CMR abnormalities in WD patients， but the combination of serum copper， WBC， and type Ⅳ collagen has a significantly better diagnostic value in identifying abnormal cardiac function in WD patients.
- Full text:2026060814055902183肝豆状核变性患者心脏MRI异常的危险因素识别及早期诊断价值指标筛选.pdf
