Cuproptosis: A novel therapeutic target for non-small cell lung cancer
- VernacularTitle:铜死亡：一种潜在的非小细胞肺癌治疗新靶点
- Author:
Dong DONG
1
;
Yajie ZHANG
1
;
Hecheng LI
1
Author Information
1. Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China
- Publication Type:Journal Article
- Keywords:
Copper;
cuproptosis;
non-small cell lung cancer;
cancer treatment;
therapeutic target
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(05):826-832
- CountryChina
- Language:Chinese
-
Abstract:
Cuproptosis, recently defined as a unique form of cell death distinct from programmed cell death, is triggered by copper overload within mitochondria. Genes associated with cuproptosis have been found to correlate with tumorigenesis and tumor progression, making the targeting of cuproptosis pathways a promising direction for anti-tumor therapies. Copper ion carriers can transport copper ions into cells, inducing cuproptosis and laying the foundation for its application in cancer treatment. This article elaborates on the homeostasis of copper and the mechanisms related to cuproptosis, further clarifying the relationship between cuproptosis and lung cancer treatment targets. This review aims to summarize current progress in research related to cuproptosis and lung cancer, providing new theories and bases for the clinical treatment of lung cancer.
