Research advances in biodegradable esophageal stents
- VernacularTitle:生物可降解食管支架的研究进展
- Author:
Chong SHEN
1
;
Kaihong WU
1
Author Information
1. Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210019, P. R. China
- Publication Type:Journal Article
- Keywords:
Biodegradable stent;
esophageal stricture;
magnesium;
polymer;
3D bioprinting;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(05):815-825
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal stricture is a common esophageal lesion in adults and children, and endoscopic dilatation is currently the standard treatment. However, high recurrence rate and frequent dilations have become a major problem in patients. Esophageal stents provide sustained dilation therapy but can lead to serious complications such as displacement, perforation, and bleeding, necessitating removal. Biodegradable stents, with the advantage of both dilation and self-degradation, are promising potential solutions to this problem. Currently, biodegradable materials are mainly categorized into metals and polymers, leading to the development of magnesium alloy esophageal stents and polymer esophageal stents. Among polymer stents, poly-L-lactic acid (PLLA) stents and SX-ELLA stents have been put into clinical application. In recent years, with the advancement of 3D bioprinting technology, the personalized fabrication of biodegradable stents has become feasible. In this paper, we will outline the current research status and progress of biodegradable magnesium alloy stents and polymer stents, introduce the new process of constructing esophageal stents by 3D bioprinting technology, focusing on the clinical research of SX-ELLA stents in pediatric and adult patients. We will also analyze the existing problems with biodegradable stents and the directions for future development.
