Experimental study on the ultrasound visibility of a novel interventional catheter and delivery system: In vitro and animal experiments
- VernacularTitle:新型介入导管与输送系统超声显影效果的体外与动物实验研究
- Author:
Ziping LI
1
;
Wenbin OUYANG
1
;
Zizheng LIU
1
;
Ning ZHOU
1
;
Jie DONG
1
;
Shouzheng WANG
1
;
Xiangbin PAN
1
,
2
Author Information
1. Department of Structural Heart Disease, Fuwai Hospital & National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Cardiovascular Diseases, Beijing, 100037, P. R. China
2. Department of Structural Heart Disease, Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen Medical Academy of Research and Translation (SMART), Shenzhen, 518057, Guangdong, P. R. China
- Publication Type:Journal Article
- Keywords:
Ultrasound-guided catheter;
ultrasound-guided delivery system;
ultrasound imaging;
in vitro characterization;
animal experiment
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(05):784-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the echogenicity of the ultrasound-guided catheter and its associated delivery system. Methods The study consisted of in vitro characterization experiments and animal studies. In the in vitro phase, the acoustic and mechanical properties of the ultrasound-guided catheter were compared with those of the traditional MPA2 catheter, including parameters such as echo intensity, recognizability, and angle dependence. In the animal experiments, a ventricular septal defect (VSD) model was established in miniature pigs to compare the procedural performance of the ultrasound-guided delivery system versus the conventional system. Evaluation indicators included the time required for the system to cross the VSD, the detection rate of the system within the right ventricle, and the occurrence of intraoperative complications. Results The ultrasound-guided catheter demonstrated a significantly higher mean echo intensity than the MPA2 catheter [(237.3±1.8) dB vs. (190.9±13.1) dB, P<0.001] and a markedly improved recognizability rate (82.3%±5.6% vs. 26.7%±3.2%, P<0.001), along with better angle independence and image quality. In animal experiments, the ultrasound-guided delivery system significantly reduced the time required to cross the VSD [(18.5±5.7) min vs. (30.3±4.5) min, P<0.001] and substantially increased the detection rate within the right ventricle (100.0% vs. 30.0%). No severe complications occurred in any experimental animal. Conclusion The ultrasound-guided catheter and its corresponding delivery system exhibite superior ultrasound visibility and operational performance in both in vitro and animal experiments, indicating strong potential for clinical application.
