Oral microbiota and colorectal cancer: mechanisms and therapeutic strategies
DOI：10.3872/j.issn.1007-385x.2026.04.001
- VernacularTitle:口腔微生物与结直肠癌：作用机制及治疗策略
- Author:
ZHANG Renyi1
1
,
2
,
3
;
YOU Fengming1,2
1
,
2
,
3
;
LI Xueke1,3
1
,
2
,
3
Author Information
1. TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;
2. Cancer Research Institute, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;
3. Oncology Teaching and Research Office, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
- Publication Type:Journal Article
- Keywords:
口腔微生物；结直肠癌；作用机制；治疗策略
- From:
Chinese Journal of Cancer Biotherapy
2026;33(4):351-362
- CountryChina
- Language:Chinese
-
Abstract:
[摘 要] 结直肠癌（CRC）是全球发病率和病死率均居前列的恶性肿瘤。除肠道微生物失衡外，近年研究证据表明口腔微生物亦在CRC发生发展中发挥关键作用。特定口腔微生物可经“口-肠”轴迁移至肠道及肿瘤组织，通过黏附定植、激活致癌信号通路、增强肿瘤细胞侵袭与迁移能力及重塑肿瘤微环境等机制促进肿瘤进展，并可能影响抗肿瘤治疗应答。这些发现提示口腔微生物在CRC临床治疗中具有潜在的应用价值。本文系统梳理口腔微生物参与CRC疾病进程的分子机制，重点阐述靶向“口-肠”轴的微生物干预策略，剖析现有研究的局限性并展望发展方向，以期为该领域的基础研究与临床转化提供参考。
- Full text:202605210930141917520260401.pdf
