Research advances on the role of gingival fibroblasts in the pathogenesis of periodontitis
10.12016/j.issn.2096-1456.202550154
- Author:
ZHANG Yong-chun
1
;
TIAN Ai
1
,
2
Author Information
1. College of Stomatology of Guizhou Medical University
2. Department of Prosthodontics and Implantology, Affiliated Stomatological Hospital of Guizhou Medical University
- Publication Type:Review
- Keywords:
periodontitis;
Porphyromonas gingivalis;
gingival fibroblasts;
neutrophils;
macrophages;
im⁃mune regulation;
cellular senescence;
Toll-like receptor 4;
nuclear factor kappa B;
mammalian target of rapamy⁃cin
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2026;34(4):395-404
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is a chronic inflammatory disease triggered by periodontal pathogens and mediated by immune responses. Traditionally, gingival fibroblasts (GFs) were considered to be primarily responsible for maintaining periodontal matrix homeostasis. However, recent studies reveal that GFs play a significant immunoregulatory role in periodontitis. Through signaling pathways, such as the Toll-like receptor 4 (TLR4) pathway, GFs recognize virulence factors from pathogens, such as Porphyromonas gingivalis, and secrete various inflammatory mediators, thus driving extracellular matrix degradation and osteoclast differentiation. Simultaneously, GFs modulate immune cells, including neutrophils and macrophages, amplifying inflammatory responses and fostering a chronic inflammatory microenvironment. Risk factors, such as hyperglycemia and smoking, exacerbate GFs dysfunction via oxidative stress-mediated activation of the nuclear factor kappa B (NF-κB) pathway and other mechanisms, while inflammation and cellular senescence form a vicious cycle. Senescent GFs further aggravate alveolar bone destruction by activating the mechanistic target of the rapamycin (mTOR) pathway. Therapeutic strategies targeting GFs, such as suppressing NF-κB signaling or modulating mTOR-mediated senescence, may disrupt the link between inflammation and tissue destruction, showing promising therapeutic potential. Future studies should employ advanced technologies such as spatial multi-omics and single-cell proteomics to elucidate the spatial distribution, functional interactomes, and heterogeneity of GFs subsets, in order to deepen our understanding of their roles in periodontitis progression. This review summarizes the multifaceted mechanisms of GFs in periodontitis and explores potential therapeutic strategies targeting GFs, offering novel insights for periodontitis prevention and treatment.
- Full text:2026052014570691241牙龈成纤维细胞在牙周炎发病机制中的作用研究进展.pdf
