Development of brush ionization probe mass spectrometry for convenient on-site detection of traditional Chinese medicine
10.1097/st9.0000000000000094
- Author:
Junxian WU
1
;
Chaofa WEI
2
;
Ceyu MIAO
3
;
Jiaquan XU
4
;
Xiang LI
5
;
Li ZHOU
5
;
Shuanglong WANG
4
;
Liping KANG
5
;
Zidong QIU
5
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
3. Field Inspection Department, Shandong Center for Medical Device Evaluation and Inspection, Jinan, China
4. Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang, China
5. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
- Publication Type:Journal Article
- Keywords:
Ambient mass spectrometry;
Brush ionization probe;
Chinese patent medicines;
Quality control;
Rapid detection
- From:
Science of Traditional Chinese Medicine
2026;4(1):81-86
- CountryChina
- Language:English
-
Abstract:
Objective: To develop a convenient, direct, and highly sensitive method for screening trace chemical additives in complex Chinese patent medicines, thereby addressing core technological bottlenecks in pharmaceutical analysis and quality control. Methods: A brush ionization probe device was independently designed and constructed, and an efficient detection method was established through systematic optimization of key parameters. Twenty-three Chinese patent medicine samples, representing 6 dosage forms (capsules, tablets, pills, granules, powders, and liquid preparations), were analyzed using 10 common chemical additives as target analytes. Results: All samples were successfully analyzed without complex pretreatment, and 5 chemical additives were detected in 7 Chinese patent medicines. The brush ionization probe device exhibited cost-effectiveness (~0.2 USD per probe), operational simplicity, rapid analysis (~10s per sample), high efficiency, and minimal reagent consumption (~10 μL per sample). Conclusion: This advancement is expected to provide an innovative scientific tool for improving the generality and convenience of on-site quality control, while promoting technological progress in disciplines such as pharmacology and traditional Chinese medicine.
