Roles of plant-derived natural compounds in the prevention and treatment of osteoporosis
10.1097/st9.0000000000000098
- Author:
Ziyi DUAN
1
;
Wenhao ZHOU
2
;
Yingjie CAI
2
;
Min ZHONG
2
;
Jian MAO
3
;
Lan JIANG
1
Author Information
1. Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation (Wannan Medical College), Central Laboratory,Yijishan Hospital of Wannan Medical College, Wuhu, China; Fuzhou University Affiliated Provincial Hospital, Central Laboratory, Fuzhou University, Fuzhou, China
2. Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation (Wannan Medical College), Central Laboratory,Yijishan Hospital of Wannan Medical College, Wuhu, China
3. Yangtze River Delta Information Intelligence Innovation Research Institute, Wuhu, China
- Publication Type:Journal Article
- Keywords:
Flavonoids;
Natural products;
Osteoporosis;
Saponins;
Terpenoids
- From:
Science of Traditional Chinese Medicine
2026;4(1):33-39
- CountryChina
- Language:English
-
Abstract:
Osteoporosis is a systemic disease, and epidemiological projections indicate that by 2050, approximately 23.43% of the Chinese population over 50 years of age will be affected. Given the poor prognosis associated with osteoporosis, the exploration of safe and effective natural products is of considerable significance. Studies investigating the chemical constituents of traditional Chinese medicine in cellular and/or animal models have demonstrated bone-protective effects. Although most of these compounds lack clinical data, they hold considerable potential as lead candidates for drug development. In-depth study of the structure-activity relationship of these natural products not only contributes to elucidating the mechanisms of action but also provides a theoretical basis for the development of novel antiosteoporosis therapies. This review summarizes natural products with potential antiosteoporotic effects reported between 2020 and 2024. Overall, plant-derived natural compounds exhibit antiosteoporotic effects by regulating bone remodeling, inflammation, and oxidative stress, highlighting their promise as multitarget therapeutic candidates.
