Natural human leukocyte antigen antibodies and corresponding clinical response strategies
10.3760/cma.j.cn421203-20240626-00152
- VernacularTitle:天然HLA抗体及相应的临床应对策略
- Author:
Junchao CAI
1
;
Duqiang ZONG
;
Lan ZHU
;
Chenhong ZHAO
;
Shengnan ZHANG
;
Lei ZHANG
;
Jun HE
;
Hongxia DAI
;
Gang CHEN
Author Information
1. 苏州才博医学研究所，苏州 215004
- Publication Type:Journal Article
- Keywords:
Organ transplantation;
Natural antibody;
Cytological antibody detection;
Complement dependent cytotoxicity
- From:
Chinese Journal of Organ Transplantation
2025;46(5):344-350
- CountryChina
- Language:Chinese
-
Abstract:
Natural human leukocyte antigen (HLA) antibodies refer to preformed antibodies present in the body that are not induced by prior exposure to allogeneic HLA antigens. In healthy individuals without a sensitization history, the detection rate of natural HLA antibodies is approximately 20%-29% when using screening assays with low sensitivity, and can reach up to 63% when more sensitive HLA-specific detection methods are employed. It is therefore inferred that natural HLA antibodies may also be present in transplant candidates with a similar prevalence. This review comprehensively discusses the potential mechanisms of natural HLA antibody generation, the characteristics of the recognized epitopes, detection techniques, clinical relevance in transplantation, their potential to confound therapeutic decisions, and approaches to distinguish and mitigate their impact. The goal is to raise clinician awareness of the objective existence of natural HLA antibodies, provide guidance on evaluating their association with allograft rejection, and inform appropriate clinical management strategies when encountering natural HLA antibody-positive transplant candidates.
