"Guangzhou Classification" of donor lung injury: a systematic evaluation and grading framework from pre-procurement to post-transplantation
10.3760/cma.j.cn421203-20250305-00038
- VernacularTitle:供肺损伤"广州分类"：从获取前到移植后的系统性评估分级
- Author:
Jianxing HE
1
;
Jiang SHI
1
;
Chao YANG
1
;
Guilin PENG
1
;
Mengyang LIU
1
;
Jiezhou HUANG
1
;
Weixue CUI
1
;
Chunrong JU
1
;
Xin XU
1
Author Information
1. 广州医科大学附属第一医院器官移植科，广州 510012
- Publication Type:Journal Article
- Keywords:
Lung transplantation;
Donor lung injury;
Guangzhou Classification;
Secondary injury
- From:
Chinese Journal of Organ Transplantation
2025;46(4):276-279
- CountryChina
- Language:Chinese
-
Abstract:
Lung transplantation is a key therapeutic approach for patients with end-stage lung diseases. Although its clinical outcomes have significantly improved, multidimensional injuries sustained by donor lungs during procurement, preservation, and transplantation remain major challenges affecting graft survival and long-term prognosis. This article proposes the "Guangzhou Classification" for full-course management of donor lung injury, characterized by spatiotemporal dynamics. Based on the progression of disease stages, donor lung injuries are systematically divided into three types: primary injuries (including donor ICU-related lung injury, pathogen colonization, and cold ischemia injury), secondary injuries (such as ventilator-induced lung injury after transplantation, ischemia-reperfusion inflammatory storm, and early rejection), and accompanying injuries (organ toxicity caused by accumulation of postoperative sedatives, analgesics, and vasoactive drugs). Drawing on previous studies and the clinical experience of our center, this paper elaborates the temporal evolution, key risk factors, and prevention and treatment strategies of each injury category, and discusses future research directions. By targeting critical injury factors at each stage, this classification aims to optimize both short-term and long-term outcomes of lung transplantation.
