Research progress in radiation-induced vascular injury
10.3760/cma.j.cn113030-20240826-00330
- VernacularTitle:放射性血管损伤的研究进展
- Author:
Junyi LIU
1
;
Yang LI
;
Dan ZONG
;
Ye ZHANG
;
Jinbo YUE
;
Qifeng WANG
;
Pei YANG
;
Wencheng ZHANG
;
Shengfu HUANG
;
Xia HE
;
Lirong WU
Author Information
1. 江苏省肿瘤医院/江苏省肿瘤防治研究所/南京医科大学附属肿瘤医院放疗科，南京 210009
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Radiation-induced vascular injury;
Mechanism;
Prevention and treatment
- From:
Chinese Journal of Radiation Oncology
2025;34(9):890-896
- CountryChina
- Language:Chinese
-
Abstract:
Due to advances in treatment methods, the survival rate and quality of life of cancer patients have been improved. Radiation-induced vascular injury (RIVI) is a common adverse reaction following radiotherapy, mainly manifested as capillary injury and atherosclerosis in the irradiated area. Radiotherapy induces RIVI in the cerebral vessels, carotid arteries, coronary arteries, and large arteries through mechanisms such as endothelial cell injury and senescence, oxidative stress and inflammatory responses, angiogenesis, and vascular remodeling. In this review research progress in the pathological features, pathophysiological mechanisms, clinical manifestations, prevention and treatment strategies of RIVI was summarized, aiming to provide insights for future research on RIVI.
