Clinical characteristics and survival analysis of nasopharyngeal carcinoma combined with multiple primary malignancies
10.3760/cma.j.cn113030-20250510-00181
- VernacularTitle:鼻咽癌合并多原发恶性肿瘤的临床特征及生存分析
- Author:
Libin ZHANG
1
;
Xiufang QIU
;
Shuyuan MAO
;
Ting XU
;
Honghong ZHANG
;
Xinyi HONG
;
Ting LIN
;
Zihan CHEN
;
Jing WANG
;
Zijie WU
;
Youliang WENG
;
Sufang QIU
Author Information
1. 福建医科大学肿瘤临床医学院/福建省肿瘤医院病案室，福州 350014
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Multiple primary malignancy;
Clinical characteristics;
Survival analysis
- From:
Chinese Journal of Radiation Oncology
2025;34(12):1183-1190
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and survival outcomes of patients with nasopharyngeal carcinoma (NPC) complicated by multiple primary malignancies (MPCs) in a real-world setting.Methods:A retrospective study was performed on 238 NPC patients with MPCs who received radical radiotherapy at Fujian Cancer Hospital between January 1st, 2004 and December 31st, 2023. The primary endpoints were overall survival (OS) and cumulative survival rate. Survival analysis was conducted using the Kaplan-Meier method with log-rank / Breslow tests, and univariate analysis of prognostic factors was performed using the Cox proportional hazards model.Results:A total of 246 primary malignant tumors were identified in 238 patients, involving 12 organ systems and 39 tumor types. The most common coexisting malignancies occurred in the respiratory and intrathoracic organs [25.2% (62/246)], followed by digestive organ malignancies [22.8% (56/246)], malignancies of the lip, oral cavity, and pharynx [22.8% (56/246)], and thyroid and other endocrine gland malignancies [15.4% (38/246)]. The median OS was 186 months, and the 3-, 5-, and 10-year cumulative survival rates were 90.84%, 85.25%, and 69.45%, respectively. Poorer survival was associated with male sex, age>48 years at onset, locally advanced disease (stage IVA), synchronous MPCs and/or digestive system malignancies, fewer total cycles of chemotherapy, and lack of concurrent or adjuvant chemotherapy.Conclusions:In patients with NPC, MPCs most frequently involve the respiratory system, digestive system, and head and neck organs (including the thyroid). Male sex, older age, locally advanced primary NPC, synchronous and/or digestive system MPCs, fewer chemotherapy cycles, and lach of concurrent or adjuvant chemotherapy were significantly associated with poorer prognosis.
