Research progress in nanoparticles in improving resistance to radiotherapy in rectal cancer

VernacularTitle:纳米粒子在改善直肠癌放射抵抗中的研究进展
Author: Hong CHEN ¹ ; Xianghu KONG ; Jing BAI ; Jianglan XU ; Yingna BAO ; Jianguo ZHAO ; Li DING
Author Information

1. 包头市肿瘤医院放疗科，包头　014000
Publication Type:Journal Article
Keywords: Nanoparticles; Rectal neoplasms; Radiotherapy resistance; Combination therapy
From: Chinese Journal of Radiation Oncology 2025;34(10):1039-1046
CountryChina
Language:Chinese
Abstract: Radiotherapy is an important part of the standard treatment regimen for rectal cancer, bringing survival benefits and improved quality of life to patients with rectal cancer. However, the radiotherapy resistance of rectal cancer patients greatly limits the effectiveness of treatment and affects the prognosis of patients. The emergence of nanoparticles provides a new way to improve radiotherapy resistance of rectal cancer, which can overcome radiotherapy resistance by inhibiting DNA damage repair, affecting cell cycle, targeting delivery, enhancing DNA damage, and regulating tumor microenvironment, etc. In this article, complex coordination mechanism leading to radiotherapy resistance in rectal cancer was reviewed, current relevant studies on nanoparticles in improving radiotherapy response in rectal cancer were summarized, and the feasibility and future research direction of the combination of nanoparticles and radiotherapy in clinical treatment of rectal cancer were discussed.