Research progress in online adaptive stereotactic radiotherapy for locally advanced pancreatic cancer
10.3760/cma.j.cn113030-20250326-00114
- VernacularTitle:局部晚期胰腺癌在线自适应立体定向放疗的研究进展
- Author:
Chen WANG
1
;
Ke HU
;
Fuquan ZHANG
;
Xin LIAN
Author Information
1. 中国医学科学院北京协和医学院，北京协和医院放射治疗科，北京 100730
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Stereotaxic techniques;
Organ motion management;
Radiotherapy, image-guided;
Adaptive radiotherapy
- From:
Chinese Journal of Radiation Oncology
2025;34(9):944-948
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy plays a critical role in the management of borderline resectable and unresectable locally advanced pancreatic cancer. Conventional radiotherapy improves local control in pancreatic cancer but has not significantly enhanced overall survival. Stereotactic body radiotherapy (SBRT), which employs single high-dose fractions or a hypofractionated regimen, enhances the biologically effective dose and has demonstrated remarkable efficacy in cancer treatment combined with systemic therapy. Due to the extremely high precision requirements of SBRT for spatial tumor targeting, precise organ motion management and image-guided radiotherapy technologies are essential for its successful implementation. The integration of MR-guided online adaptive radiotherapy with SBRT enables real-time assessment of anatomical changes during each treatment session, allowing online adaptive replanning to optimize dose delivery. This approach significantly improves treatment accuracy. The comprehensive application of these cutting-edge radiotherapy technologies holds promise for establishing groundbreaking therapeutic paradigms in pancreatic cancer.
