Fusobacterium nucleatum as a potential biomarker for screening and monitoring of colorectal cancer: a review
10.3760/cma.j.issn.1674-2397.2025.04.011
- VernacularTitle:口腔具核梭杆菌在结直肠癌筛查监测中的研究进展
- Author:
Mengpei ZHANG
1
;
Jigui CHEN
;
Hai YANG
;
Jun HU
;
Zhenwei ZOU
Author Information
1. 华中科技大学生命科学与技术学院 国家纳米药物工程技术研究中心，武汉 430074
- Publication Type:Journal Article
- Keywords:
Fusobacterium nucleatum;
Colorectal cancer;
Oral-gut microbiome axis;
Cancer screening
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(4):314-320
- CountryChina
- Language:Chinese
-
Abstract:
The emerging paradigm of tumor microecology has reshaped our understanding of carcinogenesis. Colorectal cancer（CRC），a prevalent malignancy worldwide，is not only associated with gut microbial dysbiosis but is also linked to the oral microbiome. Notably， Fusobacterium nucleatum（Fn）can translocate from the oral cavity to the colon via cross-organ migration，colonize tumor tissues，and promote CRC initiation，progression，and therapeutic resistance. This review synthesizes evidence on the association between Fn and CRC，focusing on its promise as a biomarker for early detection，risk stratification，and disease monitoring，to provide novel insights for developing Fn-based strategies for the prevention，diagnosis，and management of CRC.
