Immune-microbiota crosstalk in HBV infection: diagnostic and therapeutic implications across disease stages
- VernacularTitle:HBV感染全病程的免疫协同微生态变化及诊疗潜力
- Author:
Huilan TU
1
;
Xia YU
1
;
Xinyi XU
1
;
Longxian LYU
1
;
Xiaohan QIAN
1
;
Yu SHI
1
;
Yida YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatitis B virus; Microbiota; Host immunity; Natural history; End-stage liver disease
- From: Chinese Journal of Clinical Infectious Diseases 2025;18(4):307-313
- CountryChina
- Language:Chinese
- Abstract: Hepatitis B virus（HBV）infection poses a significant global health burden，with chronic infection driving progression to cirrhosis，hepatic failure，and hepatocellular carcinoma（HCC）. Mounting evidence implicates immune dysfunction and microbiota dysbiosis as core drivers of disease progression across all HBV infection stages. Gut and tissue-specific microbiota alterations disrupt innate/adaptive immunity，fueling inflammation，immunosuppression，and tumor immune evasion in chronic and end-stage disease. This review synthesizes mechanisms of immune-microbiota interplay in HBV pathogenesis and explores their translational potential for diagnostics and targeted interventions，including microbiota modulation and microbial biomarker applications.
