Advances in CAR-T cell targeted therapy for HIV infection: a clinical research review
10.3760/cma.j.issn.1674-2397.2025.03.010
- VernacularTitle:CAR-T细胞靶向治疗HIV感染的临床研究进展
- Author:
Xiaoshuang LUO
1
;
Di HU
;
Shoucheng JIN
;
Azhong LI
Author Information
1. 义乌市中心医院输血科，义乌 322000
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Antiretroviral therapy;
Chimeric antigen receptor T cells
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(3):224-232
- CountryChina
- Language:Chinese
-
Abstract:
HIV infection remains a critical global health challenge due to the virus’s high mutation rate enabling immune evasion and persistent transmission. While antiretroviral therapy（ART）effectively suppresses viral replication，it fails to eradicate latent viral reservoirs. Chimeric antigen receptor T cell（CAR-T）therapy，revolutionary in hematologic malignancies，shows emerging potential for HIV functional cure. Preclinical and clinical studies demonstrate that anti-HIV CAR-T cells specifically target and eliminate HIV-infected cells，yet challenges persist regarding efficacy，persistence，and safety. This review synthesizes recent advances in CAR-T cell design，clinical trial outcomes，and translational challenges，proposing novel strategies to achieve functional HIV cure.
