Advances in research on the effects of radiotherapy on peripheral blood lymphocyte subsets
10.3760/cma.j.cn113030-20240428-00161
- VernacularTitle:放疗对外周血淋巴细胞亚群影响的研究进展
- Author:
Zihan QIU
1
;
Shulian WANG
1
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京 100021
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Lymphocyte subsets;
Immune function;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2025;34(5):497-501
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy can induce peripheral blood lymphopenia, primarily due to the high radiosensitivity of peripheral blood lymphocytes and hematopoietic stem cells in the bone marrow, as well as radiation-induced apoptosis in lymphatic organs. T cells, B cells, and natural killer cells in peripheral blood comprise distinct differentiation stages and functional subsets respectively, which can be precisely characterized through flow cytometry. Radiotherapy affects both the quantity and functional activity of peripheral blood lymphocytes, with varying radiosensitivity among lymphocyte subsets, which may further influence the prognosis. These studies provide important clues for a deeper understanding of the effects of radiotherapy on immune function and for exploring potential countermeasures.
