Research progress in radiation-induced proximal bronchial tree injury
10.3760/cma.j.cn113030-20240323-00113
- VernacularTitle:放射性近端支气管树损伤的研究进展
- Author:
Aijie YANG
1
;
Haiqing WANG
;
Chao YAN
;
Yi LI
;
Zhenyu SHAO
;
Yufeng CHENG
Author Information
1. 山东大学齐鲁医院（青岛）放疗科，青岛 266000
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Proximal bronchial tree;
Radiation-induced airway disease;
Bronchial stenosis;
Pulmonary atelectasis
- From:
Chinese Journal of Radiation Oncology
2025;34(6):617-623
- CountryChina
- Language:Chinese
-
Abstract:
Radiation induced lung injury is a common complication of radiation therapy, typically characterized by the involvement of lung parenchyma.The radiation sensitivity of the trachea and bronchi is lower than that of the lung parenchyma, and the damage to the airways is usually not apparent for most patients using the standard radiation dose. The escalation of radiotherapy dose and the utilization of stereotactic body radiotherapy (SBRT) have been shown to enhance local tumor control. However, there is a growing concern regarding the development of radiation-induced airway disease (RIAD), which encompasses central airway stenosis, atelectasis, obstructive pneumonia, airway-wall necrosis, severe airway toxicity, and potentially life-threatening complications. This article presents the latest research advancements regarding the incidence, pathophysiological alterations, injury classification, preventive strategies, and treatment approaches of RIAD.
