Clinical efficacy of transcatheter edge-to-edge repair in patients with non-central degenerative mitral regurgitation
10.3760/cma.j.cn112148-20240926-00573
- VernacularTitle:经导管二尖瓣缘对缘修复治疗非中央区退行性二尖瓣反流患者的临床疗效
- Author:
Peijian WEI
1
;
Junke CHANG
;
Jianrui MA
;
Guangzhi ZHAO
;
Jing DONG
;
Cheng WANG
;
Fengwen ZHANG
;
Shiguo LI
;
Fujian DUAN
;
Wenbin OUYANG
;
Shouzheng WANG
;
Fang FANG
;
Xiangbin PAN
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院结构性心脏病中心，北京 100037
- Publication Type:Journal Article
- Keywords:
Mitral valve prolapse;
Mitral regurgitation;
Transcatheter edge-to-edge repair;
Non-central;
Commissure
- From:
Chinese Journal of Cardiology
2025;53(4):373-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of mitral valve transcatheter edge-to-edge repair (TEER) in patients with non-central degenerative mitral regurgitation (DMR).Methods:This retrospective study included patients with non-central DMR who underwent TEER at Fuwai Hospital between January 2021 and February 2024. Patients were categorized into two groups: the commissure-involved group and the non-commissure group, based on whether the mitral valve commissures were involved. Clinical data, surgical outcomes, and echocardiographic findings at 3 months postoperatively were collected and compared, and patients were followed up. The primary endpoint was the procedural success rate at discharge.Results:A total of 59 patients were included, aged (68.6±9.3) years, including 23 females (39%). In the overall study population, 78% (46/59) of patients had severe mitral regurgitation. Forty-two cases were in the non-commissure group, and 17 cases were in the commissure-involved group. Patients in the non-commissure group mainly had lesions in the A1/P1 region, while patients in the commissure-involved group mainly had lesions in the A3/P3 region. There was no significant difference in the procedural success rate at discharge (93% vs. 88%, P=0.95) and the incidence of postoperative complications (5% vs. 6%, P=1.00) between the two groups. Two patients in the commissure-involved group experienced single leaflet device attachment, with one of them requiring conversion to surgical mitral valve surgery; In the non-commissure group, two patients experienced single-valve clamping, and one of them was converted to surgical mitral valve surgery. The follow-up time of the entire cohort was (15.5±10.3) months. In the non-commissure group, 2 patients died and 2 were readmitted. While in the commissure-involved group, no patients died and only 1 patient was readmitted. Conclusion:TEER is an effective treatment for patients with non-central DMR involving the commissures, without increasing the incidence of postoperative complications.
