Multidisciplinary management of a pregnant woman with PAX2 gene variant presenting solitary kidney and chronic kidney disease stage 4: a case report
10.3760/cma.j.cn113903-20250113-00020
- VernacularTitle:PAX2基因变异致孤立肾合并慢性肾脏病4期孕妇的多学科管理1例
- Author:
Xun MAO
1
;
Xiaoling FENG
;
Xianli YANG
;
Mingfang ZHOU
;
Ping YI
;
Lili CHENG
;
Juan HUANG
;
Xin XI
;
Liyan WANG
;
En TIAN
;
Lirong LIN
;
Jurong YANG
;
Yao FAN
;
Lili YU
Author Information
1. 重庆医科大学附属第三医院妇产中心，重庆 401120
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
End stage renal disease;
Pregnancy;
Hemodialysis;
Multidisciplinary collaboration
- From:
Chinese Journal of Perinatal Medicine
2025;28(12):1136-1142
- CountryChina
- Language:Chinese
-
Abstract:
Pregnancy with chronic kidney disease (CKD), particularly in stages 4-5, carries high risks of adverse outcomes including maternal renal failure, preeclampsia/eclampsia, fetal growth restriction, and preterm birth. This report described a 26-year-old woman with congenital solitary kidney, polycystic ovaries, and uterine septum due to PAX2 gene variant, complicated by CKD stage 4. Through multidisciplinary team precision management and individualized treatment strategies, including timely initiation of dialysis, the patient successfully maintained pregnancy until 34 +1 weeks and delivered a female infant via cesarean section. This case summarizes key management experiences for end-stage renal disease in pregnancy, highlighting early risk assessment, precise nutritional management, hemodialysis protocol optimization, and the crucial role of multidisciplinary collaboration, providing valuable references for managing CKD-complicated pregnancies.
