Effect of hyperbaric oxygen combined with drugs on nerve damage caused by nitrous oxide poisoning
10.3760/cma.j.cn311847-20210802-00222
- VernacularTitle:高压氧联合药物治疗笑气中毒致神经损害的疗效分析
- Author:
Lu ZHANG
1
;
Yiqun WANG
1
;
Jia CHEN
1
;
Hanchun WANG
1
;
Dongzhang XUE
1
;
Rui AI
1
;
Jincheng CHENG
1
;
Shiquan YANG
1
Author Information
1. 联勤保障部队第九○二医院高压氧神经内科，蚌埠 233000
- Publication Type:Journal Article
- Keywords:
Nitrous oxide poisoning;
Hyperbaric oxygen;
Nerve damage;
Neuroelectrophysiology
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(2):208-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of drugs combined with hyperbaric oxygen（HBO）on nervous system damage caused by nitrous oxide（N 2O）poisoning. Methods:The clinical data of 12 patients with nerve damage caused by N 2O poisoning admitted to the Department of Neurology，Hyperbaric Oxygen of a certain PLA hospital from February 2020 to April 2021 were reviewed. The changes of neuroelectrophysiological and neurological functions of patients before and after treatment were analyzed using electroneurogram detection，Berg balance scale，and Holden’s functional ambulation categories（FAC）as observation indicators. Results:After drug treatment combined with HBO，the motor conduction velocity，sensory conduction velocity，motor latency，motor evoked potential，and sensory evoked potential of electroneurogram of 12 patients were significantly improved，and the differences were statistically significant（ P < 0.05）.Berg balance scale scores were significantly improved compared with those before treatment，and the differences were statistically significant（ P < 0.05）.FAC scale was improved compared with before treatment，but the difference was not statistically significant（ P > 0.05）. Conclusion:HBO combined with folic acid，vitamin B12 and other neurotrophic drugs has a certain clinical effect in the treatment of nerve damage caused by N 2O poisoning，which is worthy of further study and improvement.
