Effects of hyperbaric oxygen on inflammatory factors and wound healing in patients with perianal abscess after operation
10.3760/cma.j.cn311847-20210517-00157
- VernacularTitle:肛周脓肿患者术后高压氧处理对炎性因子及创面愈合的影响
- Author:
Guimei LI
1
;
Lijuan LIANG
;
Yanhai MA
Author Information
1. 安阳市第三人民医院大外科，安阳 455000
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Perianal abscess;
Wound healing;
Inflammatory factors
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(1):99-101,107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of hyperbaric oxygen intervention on inflammatory factors and wound healing in patients with perianal abscess after operation.Methods:A total of 70 patients who undergone one-time radical perianal abscess incision and drainage in the Anyang Third People’s Hospital from July 2018 to December 2019 were selected and single-blindly grouped into control group and study group by using the envelope method，with 35 cases in each group. The control group received conventional dressing change after operation，while the study group additionally received postoperative hyperbaric oxygen therapy starting from the day of operation. The wound healing，the level of inflammatory factors 10 days after the operation，and the occurrence of complications in the two groups were observed.Results:The wound healing time of the study group was significantly shorter than that of the control group（ P<0.05），and the wound area reduced rate was significantly greater than that of the control group（ P<0.05）. After 10 days of treatment，the levels of serum activin-A（ACTA），interleukin 6（IL-6），and C-reactive protein（CRP）in both groups were significantly lower than those before treatment（ P<0.01），and the serum levels of IL-6 and CRP in the study group were significantly lower than those in the control group（ P<0.05），but there was no statistically significant difference between the ACTA levels of the two groups（ P>0.05）. There was no statistically significant difference in the incidences of wound allergy，granulomatous edema，and eczema，nor in the total incidence of complications between the two groups after treatment（ χ2=2.155， P=0.133）. Conclusion:Hyperbaric oxygen intervention can effectively promote wound healing after perianal abscess operation，reduce inflammatory factors，and has high safety. It can be further promoted and applied in clinical practice.
