Curative effect of hyperbaric oxygen assisted butylphthalide patients with acute ischemic stroke and their influence on serum ET-1，TXB2 and VEGF levels
10.3760/cma.j.cn311847-20210423-00126
- VernacularTitle:高压氧辅助丁苯酞治疗急性缺血性脑卒中患者的疗效及对血清ET-1、TXB2及VEGF水平的影响
- Author:
Jing LIU
1
;
Huifang NING
;
Qin WU
Author Information
1. 山西省人民医院药学部，太原 030012
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Hyperbaric oxygen;
Butylphthalide;
Endothelin-1;
Thromboxane B2;
Vascular endothelial growth factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of hyperbaric oxygen-assisted butylphthalide on patients with acute ischemic stroke and the effects of serum endothelin-1（ET-1），thromboxane B2（TXB2）and vascular endothelial growth factor（VEGF）levels.Methods:A total of with acute ischemic stroke were selected，and randomly divided into two groups（according to the order of admission）. The control group was treated with butylphthalide，and the combined group was treated with hyperbaric oxygen-assisted butylphthalide，the treatment time was 14 days. The National Institutes of Health Stroke Scale（NIHSS）score and Barthel index score，clinical efficacy，serum ET-1，TXB2 and VEGF levels，coagulation function，hemorheology index，and adverse reactions between the two groups of patients were compared.Results:Compared with before treatment，the NIHSS scores of the two groups of patients were significantly reduced after treatment（ P<0.05），and the NIHSS scores of the combined group after treatment were significantly lower than those of the control group（ P<0.05）. After treatment，the Barthel index scores of the two groups were significantly higher than those before treatment（ P<0.05），and after treatment，compared with the control group，the combination group had significantly higher Barthel index（ P<0.05）. After treatment，there was a significant difference in the distribution of curative effects between the two groups，and compared with the control group（88.03%），the total effective rate of combined group（95.77%）was significantly higher（ χ 2=5.724， P<0.05）. Compared with before treatment，serum ET-1 and TXB2 levels of the two groups were significantly lower after treatment，compared with the control group，the serum ET-1 and TXB2 levels of combination group were significantly lower，the VEGF levels of the two groups were significantly higher than before treatment，and compared with the control group，the combination group had significantly higher VEGF levels（ P<0.05）. Compared with before treatment，thrombin time（TT），prothrombin time（PT），activated partial thromboplastin time（APTT）in both groups were higher after treatment，and the TT，PT，and APTT of the combination group were significantly higher than those of control group（ P<0.05）. There were no statistically significant difference in incidence of adverse reactions between the two groups（ P>0.05）. Conclusion:Hyperbaric oxygen-assisted butylphthalide has a significant clinical effect on the treatment of patients with acute ischemic stroke，and reduce vascular endothelial damage，improve blood coagulation function and hemorheology，and it is safe and reliable.
