Meta-analysis of the clinical efficacy of hyperbaric oxygen as adjunctive therapy for neurological tinnitus
10.3760/cma.j.cn311847-20201125-00442
- VernacularTitle:高压氧辅助治疗神经性耳鸣疗效的Meta分析
- Author:
Xiubing GONG
1
;
Yanan GU
;
Xiangyue JIANG
;
Yehao LUO
;
Qingli DOU
Author Information
1. 510515 广州，南方医科大学第二临床医学院
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Neurological tinnitus;
Meta-analysis
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):622-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of hyperbaric oxygen as adjunctive therapy for neurological tinnitus (NT).Methods:Relevant clinical studies in eight databases (PubMed, Embase, Cochrane library, Web of Science, CBM, Cqvip, Wanfang data, and CNKI) were systematically searched, and data from the relevant studies were extracted based on inclusion and exclusion criteria. The methodological quality assessment of the data was conducted by using the Cochrane Collaboration’s tool for assessing risk of bias, the data analysis was conducted by using RevMan 5.3, and the sensitivity analysis of publication bias detection was conducted by using Stata 15.Results:A total of 12 randomized controlled trials (RCTs) were included. The results of meta-analysis showed that hyperbaric oxygen therapy had sound clinical efficacy in treating NT [ OR=4.10, 95% CI (2.81, 5.98), P<0.01]. It also reduced the scores of tinnitus severity index [ WMD=11.38, 95% CI (10.53, 12.23), P<0.01]. There was obvious asymmetry in the funnel diagram, and Egger’s test results ( t=2.96, P<0.05) indicated publication bias. Conclusion:Hyperbaric oxygen as adjunctive therapy for neurological tinnitus can effectively reduce tinnitus severity, which is superior to conventional treatment alone.
