Clinical efficacy of alendronate combined with hyperbaric oxygen on elderly patients with osteoporosis and its effect on serum bone metabolism
10.3760/cma.j.cn311847-20201012-00378
- VernacularTitle:阿伦磷酸钠联合高压氧治疗对老年骨质疏松症患者的临床疗效及血清骨代谢的影响
- Author:
Hongcai DONG
1
;
Chen WANG
1
;
Guangxin WANG
1
;
Zheng FAN
1
Author Information
1. 110031 沈阳，沈阳市第四人民医院骨科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Alendronate;
Osteoporosis;
Clinical efficacy;
Bone metabolism
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):634-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of alendronate combined with hyperbaric oxygen on elderly patients with osteoporosis (OP) and its effect on serum bone metabolism.Methods:A total of 80 elderly patients with OP admitted to the Department of Orthopedics of the Fourth People’s Hospital of Shenyang from January 2017 to December 2019 were selected and divided into control group ( n=40) and observation group ( n=40) by the random number table method. The control group received alendronate, while the observation group received alendronate combined with hyperbaric oxygen treatment. Both groups received six months of treatment. Fasting venous blood was collected before and after treatment, and serum levels of N-terminal osteocalcin (N-MID), bone-specific alkaline phosphatase (BAP), N-terminal propeptide of type I procollagen (PINP), and carboxy-terminal peptide of type I collagen (CTX) in the two groups were measured by electrochemiluminescence immunoassay (ECLI). The scores of numeric rating scale (NRS) for pain assessment were collected before and after treatment; and the clinical efficacies of the two groups after treatment were observed. Results:The total effective rate of the observation group (85.00%) was significantly higher than that of the control group (65.00%); after treatment, the NRS score of the observation group was significantly lower than that of the control group; the levels of serum N-MID, BAP, PINP, and CTX in the observation group were significantly lower than those in the control group; all the differences were statistically significant ( P<0.05). Conclusion:Alendronate combined with hyperbaric oxygen can reduce the levels of serum N-MID, BAP, PINP, and CTX in elderly patients with OP and relieve their pain significantly with good clinical efficacy, which can be widely used in clinical practice.
