Effects of different courses of hyperbaric oxygen combined with sertraline on sleep disorders and serum neurologic injury factors in patients after cerebral hemorrhage
10.3760/cma.j.cn311847-20210127-00034
- VernacularTitle:不同疗程高压氧联合舍曲林治疗对脑出血患者睡眠障碍及血清神经损伤因子的影响
- Author:
Zhixu WANG
1
;
Jin LI
;
Pengfei MENG
;
Jicun DONG
;
Xue CAI
;
Baoyuan ZHAO
;
Lijuan MU
Author Information
1. 733000 甘肃省武威，武威市人民医院药剂科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Sertraline;
Sleep disorders after cerebral hemorrhage;
Neuron-specific enolase;
Intercellular adhesion molecule-1;
Tumor necrosis factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):589-593,598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effects of different courses of hyperbaric oxygen combined with sertraline on sleep disorders and serum neurologic injury factors in patients after cerebral hemorrhage.Methods:A total of 120 patients with sleep disorders after cerebral hemorrhage were divided into control group ( n=60) and observation group ( n=60) by random number table method. The control group was treated with sertraline only, while the observation group was treated with hyperbaric oxygen on the basis of the treatment in the control group. The sleep quality, clinical efficacy, the levels of serum neuron-specific enolase (NSE), intercellular adhesion molecule-1 (ICAM-1), and tumor necrosis factor-α (TNF-α) before and 10, 20, and 30 d after treatment were compared between the two groups. Results:The scores of Pittsburgh sleep quality index (PSQI) of the observation group were significantly lower than those of the control group at every time point of treatment ( P<0.05); the total sleep time, total deep sleep time, total light sleep time, and rapid eye movement (REM) sleep time of the observation group were significantly longer than those of the control group ( P<0.05); and the sleep latency of the observation group was significantly shorter than that of the control group ( P<0.05). With the prolongation of the treatment course, the PSQI scores of both groups showed decreasing trends ( P<0.05); the total sleep time, total deep sleep time, total light sleep time, and REM sleep time of both groups tended to prolong ( P<0.05); and the sleep latency tended to be shorter ( P<0.05). The total effective rate of the observation group was significantly higher than that of the control group at 10, 20, and 30 d after treatment ( P<0.05). With the prolongation of the treatment course, the total effective rates of the two groups showed increasing trends ( P<0.05); the levels of serum NSE, ICAM-1, and TNF-α in the observation group were significantly lower than those in the control group at every time point of treatment ( P<0.05); and with the prolongation of the treatment course, the above indicators of the two groups showed decreasing trends ( P<0.05). Conclusion:Hyperbaric oxygen therapy combined with sertraline can improve the sleep quality and clinical efficacy of patients after cerebral hemorrhage with sleep disorders.
