Effects of early hyperbaric oxygen combined with piracetam on hepatic and renal function and myocardial enzyme spectrum in patients with acute carbon monoxide poisoning
10.3760/cma.j.cn311847-20201105-00415
- VernacularTitle:早期高压氧联合吡拉西坦治疗对急性一氧化碳中毒患者肝肾功能及心肌酶谱的影响
- Author:
Jing LI
1
;
Lin LIU
;
Linlin GU
;
Luheng GUO
;
Qiaosheng WANG
;
Xiangjie GUO
Author Information
1. 272100 山东省济宁，济宁医学院附属医院急诊科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Piracetam;
Acute carbon monoxide poisoning;
Renal function;
Hepatic function;
Myocardial enzyme spectrum
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):594-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of early hyperbaric oxygen combined with piracetam on hepatic and renal function and myocardial enzyme spectrum in patients with acute carbon monoxide poisoning (ACOP).Methods:A total of 103 patients with ACOP treated in the Emergency Department of Affiliated Hospital of Jining Medical University from January 2015 to January 2019 were selected and divided into control group (53 cases, hyperbaric oxygen treatment) and observation group (50 cases, hyperbaric oxygen combined with piracetam treatment). The changes in the renal function, myocardial enzyme spectrum, superoxide dismutase (SOD), and the hepatic function, as well as the clinical efficacy, and the incidences of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group (98.00%) was significantly higher than that of the control group (79.25%), and there was a statistically significant difference ( P<0.05). After treatment, the levels of blood urea nitrogen (BUN), creatinine (Cr), uric acid, β2 microglobulin (β2-MG), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), α-hydroxybutyrate dehydrogenase (α-HBDH), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in the observation group were lower than those in the control group, while the level of SOD in the observation group was higher than that in the control group, and there were statistically significant differences ( P<0.05). In terms of the incidences of delayed encephalopathy, acute cerebral infarction, rhabdomyolysis, and pressure ulcer, there was no statistically significant difference between the two groups ( P>0.05). Conclusion:The early hyperbaric oxygen combined with piracetam has a significant clinical efficacy in treating patients with ACOP. It can alleviate the myocardial damage caused by hypoxia, and plays a positive role in protecting hepatic and renal function.
