Therapeutic effect of hyperbaric oxygen therapy on acute ischemic stroke and its effects on lipid metabolism, serum IL-1β, IL-6, and TNF-α levels
10.3760/cma.j.cn311847-20200111-00013
- VernacularTitle:高压氧治疗急性缺血性脑卒中的疗效及对脂质代谢与血清IL-1β、IL-6、TNF-α水平的影响
- Author:
Huixian LI
1
;
Mingming XIN
;
Jiyuan LI
;
Weiwei REN
Author Information
1. 030000 太原，山西医科大学第一医院急诊科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Acute ischemic stroke;
Lipid metabolism;
IL-1β;
IL-6;
TNF- α
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(4):464-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effect of hyperbaric oxygen therapy (HBOT) on acute ischemic stroke (AIS) and its effects on lipid metabolism, serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).Methods:A total of 84 AIS patients treated in the First Hospital of Shanxi Medical University from January 2017 to January 2020 were enrolled and divided into observation group ( n=42) and control group ( n=42) by random number table method. The control group received conventional treatment, while the observation group received conventional treatment combined with HBOT. The indicators related to lipid metabolism, the levels of serum inflammatory medicators, brain microcirculation, and prognosis were compared between the two groups. Results:After treatment, the levels of the total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were significantly decreased, and the level of high-density lipoprotein cholesterol (HDL-C) was significantly increased in both groups ( P<0.05); and compared with the control group, the observation group had significantly lower LDL-C level and significantly higher HDL-C level ( P<0.05). After treatment, the levels of serum IL-1β, IL-6, and TNF-α were significantly decreased in both groups, and the three indicators in the observation group were all significantly lower than those in the control group ( P<0.05). The systolic velocity (Vs), diastolic velocity (Vd), and mean velocity (Vm) on the healthy side of carotid artery of the patients in both groups had no significant changes after treatment ( P>0.05), while Vs, Vd, and Vm on the affected side of carotid artery of the patients were significantly increased ( P<0.05), and all of them were significantly higher in the observation group than those in the control group ( P<0.05). Before treatment, the activity of daily living (ADL) score and clinical neurological function deficit (CNFD) score showed no significant difference between the two groups (all P>0.05). After treatment, there was an increase in the ADL scores increased and a decrease in CNFD scores decreased in both groups, and the observation group had significant higher ADL scores and CNFD scores than those of the control group [(73.99±11.15) vs. (54.69±12.03), (8.64±2.25) vs. (12.31±2.03); all P<0.05]. Conclusion:HBOT can effectively reduce the lipid metabolism disorders in AIS patients, alleviate their inflammatory response, improve their brain microcirculation, neurological function deficits, and the activity of daily life, so as to ensure the therapeutic effect.
