Effects of hyperbaric oxygen-assisted hemoperfusion on renal function and immune inflammatory cytokines in patients with end-stage diabetic nephropathy
10.3760/cma.j.cn311847-20200422-00156
- VernacularTitle:高压氧辅助血液透析联合灌流治疗对终末期糖尿病肾病患者肾功能及免疫炎性因子的影响
- Author:
Chuanmei HE
1
;
Jinxiu LIU
;
Hui LI
;
Xiaodong LIU
;
Guanghao FU
;
Wenbin SHI
;
Tongdao XU
Author Information
1. 222000 江苏省连云港，连云港市第二人民医院肾内科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Diabetic nephropathy;
Renal function;
Immune inflammatory cytokines
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(4):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of hyperbaric oxygen-assisted hemoperfusion on renal function and immune inflammatory cytokines in patients with end-stage diabetic nephropathy (ESDN).Methods:A total of 92 patients with ESDN admitted to the Department of Nephrology of the Second People’s Hospital of Lianyungang from June 2016 to December 2017 were randomly divided into control group ( n=46) and observation group ( n=46). The control group was given conventional treatment and the combination of hemodialysis with hemoperfusion, while the observation group was treated with hyperbaric oxygen on the basis of the treatments of the control group. The levels of fasting blood glucose (FBG), 24-hour urinary protein (24 h Upro), blood urea nitrogen, creatinine (Cr), uric acid and albumin (ALB), and the contents of immune inflammatory cytokines such as interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-17 (IL-17), monocyte chemoattractant protein-1 (MCP-1), and hypersensitive C-reactive protein (hs-CRP) were compared between the two groups before and after treatment. Results:After treatment, the levels of FBG, renal function indicators, and the contents of immune inflammatory cytokines in the two groups were significantly improved in comparison with those before treatment ( P<0.05). The levels of Cr, 24 h Upro, and ALB in the observation group were (482.54±166.46) μmol/L, (1 095.34±154.78) mg, and (33.04±3.91) g/L, respectively, which were significantly better than those in the control group ( P<0.05). The improvements in IL-6, IL-10, IL-17, MCP-1, and hs-CRP contents in the observation group were significantly better than those in the control group ( P<0.05). The incidences of complications such as hypoglycemia, hypoxemia, hypotension, infection, and cardio-cerebrovascular events in the observation group were also significantly lower than those in the control group ( P<0.05). Conclusion:Hyperbaric oxygen-assisted hemoperfusion can effectively inhibit vascular endothelial injury due to inflammatory irritation and restore renal microvascular circulation to improve renal function by reducing the contents of IL-6, IL-17, MCP-1, and hs-CRP, and increasing IL-10 content in ESDN patients.
