Changes of physiological indexes of human body at two altitudes in plateau simulation
10.3760/cma.j.cn311847-20200721-00295
- VernacularTitle:模拟高原两种海拔高度环境人体生理指标的变化
- Author:
Bing MENG
1
;
Jing HAN
1
;
Mingchun WEN
1
;
Tiantian XIA
1
;
Shuping ZHANG
1
;
Dianbo KOU
1
;
Fubin SUN
1
;
Peng QI
1
;
Chunhua WEI
1
Author Information
1. 261041 山东省潍坊，潍坊卫恩医院
- Publication Type:Journal Article
- Keywords:
Plateau;
Plateau reaction;
Pulse oxygen;
Blood gas analysis;
Blood routine
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the physiological changes of people when advancing rapidly to the plateau, and to evaluate the performance of high-altitude simulation device.Methods:A total of 24 healthy volunteers were randomly divided into 4 groups with 6 individuals in each by the random number table method. The high-altitude simulation device was used to simulate the plateau in two stages. The first stage simulated an altitude of 3 500 m (equivalent to high altitude), and the second stage was performed after an interval of 24 hours from the first stage, which simulated an altitude of 5 000 m (equivalent to ultra-high altitude). During the two stages, for blood routine and blood gas analysis, blood samples were taken before entering the chamber of each stage, and at the simulated altitudes of 3 500 and 5 000 m in the chamber. Furthermore, ECG tests were also conducted before and after entering the chamber. In the case of cardiac abnormality, the cardiac enzyme test would be carried out. Meanwhile, one volunteer in each group was under ECG monitoring.Results:As the simulated altitude increased, the volunteers’ pulse rates increased gradually, while their saturation of periferal oxygen(SpO 2) decreased gradually. Comparing the pulse rate and SpO 2 at 3 500 m with those before entering the chamber, and comparing the pulse rate and SpO 2 at 5 000 m with those before entering the chamber; all the differences were statistically significant ( P<0.05, or P<0.01). The blood routine tests demonstrated a significant increase in the total counts of red blood cells, hemoglobin, platelets and white blood cells and other contents at the first stage, i. e., 3 500 m; and the differences were statistically significant compared with those before entering the chamber ( P<0.05, or P<0.01). Furthermore, the pH values increased gradually, whereas arterial partial pressure of oxygen (PaO 2), oxygen saturation (SaO 2), and arterial partial pressure of carbon dioxide (PaCO 2) decreased gradually. The significant decrease in HCO 3- showed at 5, 000 m, and the differences were statistically significant compared with those before entering the chamber ( P<0.05, or P<0.01). Conclusion:The plateau simulation can reflect physiological changes of the human body after advancing rapidly to the plateau under the premise of ensuring safety. It has laid a foundation for the further implementation of plateau acclimatization on plain area.
