Research progress on the etiology and prevention of acute gallstone pancreatitis
10.3760/cma.j.cn113884-20241029-00321
- VernacularTitle:急性胆石性胰腺炎病因学防治方法的研究进展
- Author:
Ao WANG
1
;
Yanan ZHANG
;
Li ZHANG
;
Xiande GUO
;
Ning LI
Author Information
1. 天津医科大学南开临床学院，天津 300100
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Gallstone;
Etiology;
Prophylaxis and treatment
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(2):150-155
- CountryChina
- Language:Chinese
-
Abstract:
Acute gallstone pancreatitis (AGP) represents an acute inflammatory condition of the pancreas, of which etiology and prevention require systematic understanding from the molecular mechanisms of onset, combined with the foundations of pathological anatomy and pathophysiological processes. Main pancreatic duct obstruction and bile acid reflux are the primary causes of AGP. The duration of the obstruction is particularly crucial to its progression, and early intervention in pancreatic duct obstruction is key to preventing severe cases. The management strategy for AGP in its early stages includes endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, and endoscopic sphincterotomy. The core of diagnosis and treatment involves promptly identifying the cause, relieving bile and pancreatic duct obstruction, reducing pressure in the pancreatic duct, implementing common bile duct drainage, and evaluating the effect of pancreatic duct stenting. Since gallstones are the only controllable factor, early cholecystectomy is the safest choice for preventing AGP. However, the timing and methods of etiological prevention and treatment of AGP still require further research. This article synthesizes insights into anatomical factor management, gallstone prevention, interruption of the onset process, and coordination of prevention mechanisms, aiming to provide a reference for AGP prevention and treatment.
