Correlation between FeNO in bronchial dilation test in patients with chronic moderate to severe persistent asthma
10.3760/cma.j.cn311847-20191218-00404
- VernacularTitle:中重度哮喘呼出气一氧化氮与支气管舒张试验相关性的研究
- Author:
Xiaoru WANG
1
;
Ling WU
;
Zhi ZHANG
;
Qinghua KONG
;
Hui QI
;
Han LEI
Author Information
1. 200237 上海，上海市徐汇区大华医院呼吸内科
- Publication Type:Journal Article
- Keywords:
Asthma;
FeNO;
Bronchial dilation test
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(3):331-333,337
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the dynamic changes in fractional exhaled nitric oxide (FeNO) and the rates of change of forced expiratory volume in the first second (FEV1) in the bronchial dilation test, and their correlation in patients with chronic moderate to severe persistent asthma during escalation therapy.Methods:A total of 160 patients with chronic moderate to severe persistent asthma were given escalation therapy according to the Global Initiative for Asthma (updated in 2015). FeNO concentrations, the Asthma Control Questionnaire (ACQ), and the bronchial dilation test were taken every 3 months over 1 year.Results:After receiving standardized therapy, the ACQ scores of the 160 patients gradually declined, and both their FeNO concentrations and the rates of change of FEV1 decreased, showing significant correlation.Conclusion:After the escalation therapy on chronic moderate to severe persistent asthma, the dynamic changes in FeNO concentrations were positively correlated with that of the rates of change in FEV1 in the bronchial dilation test, which can provide a theoretical reference to the standardized management and treatment of chronic moderate to severe persistent asthma in basic level hospitals.
