Association study on abdominal aortic hemodynamic parameters based on four-dimensional flow MRI with renal function in chronic kidney disease
10.3760/cma.j.cn112149-20241124-00698
- VernacularTitle:基于四维血流MRI的腹主动脉血流动力学指标与慢性肾病患者肾功能的相关性研究
- Author:
Qinling ZONG
1
;
Liang PAN
;
Hua ZHOU
;
Zhenxing JIANG
;
Jiule DING
;
Nan SHEN
;
Jie CHEN
;
Wei XING
Author Information
1. 扬州大学医学院，扬州 225001
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Four-dimensional flow;
Chronic kidney disease;
Abdominal aorta;
Arterial compliance;
Hemodynamics
- From:
Chinese Journal of Radiology
2025;59(2):212-217
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between renal function and abdominal aortic hemodynamic parameters based on four-dimensional flow(4D Flow) MRI in patients with chronic kidney disease (CKD).Methods:A cross-section prospective study was conducted on 73 patients diagnosed with CKD at First People′s Hospital of Changzhou between March 2021 and May 2023, as well as 13 volunteers without kidney injury. According to the estimated glomerular filtration rate (eGFR), the subjects were divided into CKD 1-3 stage group ( n=34), CKD 4-5 stage group ( n=39), and control group ( n=13). All subjects underwent 4D Flow MRI examination of the abdominal aorta, measuring pulse wave velocity (PWV), peak velocity, and maximum wall shear stress (WSS) at the proximal plane (Plane_1) and the higher renal artery opening plane (Plane_2) of the abdominal aorta. The differences in 4D Flow MRI hemodynamic parameters among the three groups were compared using a one-way analysis of variance or the Kruskal-Wallis test. The correlation between 4D Flow MRI hemodynamic parameters and eGFR was analyzed by using the Spearman correlation coefficient. The independent influencing factors that affect eGFR were analyzed by using multivariate linear regression analysis. Results:There were significant differences in abdominal aortic PWV and maximal WSS of Plane_1 and Plane_2 among the three groups ( H=10.38, P=0.006; F=11.16, P<0.001; F=4.75, P=0.011). There were no significant differences in the peak velocity of Plane_1 and Plane_2 among the three groups (both P>0.05). Abdominal aortic PWV was negatively correlated with eGFR ( r s=-0.30, P=0.005). There was a positive correlation between the maximal WSS of Plane_1 and Plane_2 with eGFR ( r s=0.39, P<0.001; r s=0.29, P=0.006). Abdominal aortic PWV and maximal WSS of Plane_1 were independent influencing factors of eGFR (b=-4.32, P=0.018; b=132.23, P=0.004). Conclusions:There is an independent correlation between renal function and abdominal aortic hemodynamic parameters based on 4D Flow MRI in patients with CKD, and abdominal aortic PWV and maximal WSS of Plane_1 were independent influencing factors of eGFR.
