Clinical analysis of urinary system in patients with IgG4 related disease
10.3760/cma.j.cn141217-20241004-00284
- VernacularTitle:IgG4相关疾病患者泌尿系受累的临床特征分析
- Author:
Piaopiao GUO
1
;
Junyu LIANG
;
Yongjun CHENG
;
Heng CAO
;
Jin LIN
Author Information
1. 浙江大学医学院附属第一医院风湿免疫科，杭州 310003
- Publication Type:Journal Article
- Keywords:
IgG4-related Disease;
Renal and urinary lesions;
Clinical features;
Prognosis;
Risk factors
- From:
Chinese Journal of Rheumatology
2025;29(10):846-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the clinical characteristics of the urinary system involvement in patients with IgG4-related disease (IgG4-RD), and to identify the risk factors for progression to glomerular filtration rate (GFR) less than 60 ml/min.Methods:A retrospective review was carried out using the medical records of 71 cases with IgG4-RD complicated with renal and urinary lesions diagnosed in the First Affiliated Hospital of Zhejiang University School of Medicine between January 2017 and December 2021. Cox proportional hazards model was performed to assess the factors associated with the risk of GFR<60 ml/min.Results:We studied 71 patients with IgG4-RD who had renal and urinary lesions with a mean follow-up of (31.5±19.5)months. Among these, 60 patients were male, and the mean disease onset age was (63.1±10.8)years, and 41(57.7%) patients had IgG4-related kidney disease (IgG4-RKD). Twenty-four patients had IgG4-RKD confirmed after kidney biopsy, with all biopsies showing tubulointerstitial nephritis and one showing membranous nephropathy. Urine immunoglobulin G[ HR(95% CI)=1.218(1.026, 1.446), P=0.025] was associated with a higher risk of GFR less than 60 ml/min. Conclusion:The most common type of urinary system involvement in patients with IgG4-RD is IgG4-RKD. Meanwhile the most common pathological type of IgG4-RKD is TIN. Urine immunoglobulin G is associated with a higher GFR less than 60 ml/min rate.
