Progress of the interaction network between macrophages and T cells in the glioma tumor microenvironment
10.3760/cma.j.cn115355-20240412-00173
- VernacularTitle:胶质瘤微环境中巨噬细胞与T细胞相互作用网络研究进展
- Author:
Xuanchen LIU
1
;
Guijun JIA
1
;
Chunhong WANG
1
;
Hongming JI
1
Author Information
1. 山西医科大学附属山西省人民医院神经外科，太原 030012
- Publication Type:Journal Article
- Keywords:
Glioma;
Macrophages;
Regulatory T cells;
Tumor microenvironment
- From:
Cancer Research and Clinic
2025;37(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is the most common primary malignant brain tumor and its microenvironment exhibits immunosuppressive properties. Macrophages and T cells are the main immune cells of glioma, which engage in highly dynamic interactions. Cytokines such as interleukin-2 (IL-12), interleukin-10 (IL-10), interferon-γ (IFN-γ),and transforming growth factor-β (TGF-β) determine the direction and intensity of the anti-tumor immune response through finely regulating macrophage polarization and T cell subset differentiation. Co-stimulatory molecules on the surface of T cells are mostly members of the immunoglobulin superfamily (IgSF); in addition,co-stimulatory molecules including CD80/CD86, T cell inducible co-stimulatory molecule and its ligand (ICOS /ICOS-L),CD40L/CD40, OX40L/OX40 and glucocorticoid-induced tumor necrosis factor receptor related protein and its ligand (GITR /GITR-L) are involved in initiating,enhancing or inhibiting T cell activation,and collaboratively shape the overall tumor immune microenvironment. The in-depth understanding of these factors and molecular pathways can help optimize immunotherapeutic strategies for glioma and provide new therapeutic targets.
