Local injections of glucocorticoids at different regions in the treatment of sudden sensorineural hearing loss: a Meta-analysis
10.3760/cma.j.cn115330-20240416-00216
- VernacularTitle:不同部位局部注射糖皮质激素治疗突发性聋的Meta分析
- Author:
Tianwei CHEN
1
;
Haoyuan ZHU
;
Jiahao NI
;
Longkui JIANG
;
Jianguo DAI
Author Information
1. 南京中医药大学医学院临床医学专业，南京 210023
- Publication Type:Journal Article
- Keywords:
Hearing loss, sudden;
Glucocorticoids;
Meta-analysis;
Postauricular injection;
Intratympanic injection;
Drug administration routes
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2025;60(1):10-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of postauricular injection (PI) and intratympanic injection (II) of glucocorticoids (GC) in the initial treatment of sudden sensorineural hearing loss (SHL).Methods:Electronic databases retrieval (PubMed, Web of Science, CNKI, VIP, WANFANG) was performed to identify all randomized controlled trials about PI and II of GC in the initial treatment of SHL between 2015 and 2024. Meta-analysis was performed on the studies met the inclusion criteria by RevMan5.4.Results:A total of 971 articles were retrieved, and 23 Chinese articles were included after screening. Meta-analysis found that the total effective rate of PI was significantly higher than that of II ( OR=1.37, 95% CI:1.15-1.65, P=0.000 6), with higher recovery of the hearing threshold (SMD=1.24, 95% CI:0.01-2.46, P=0.05) and a lower incidence of adverse reactions and complications ( OR=0.20, 95% CI:0.15-0.28, P<0.000 01). Conclusions:Compared with II, PI has a better efficacy and safety. Nonetheless, whatever topical administration of GC that can be regarded as the first choice of initial therapeutic schedules to SHL requires further studied.
