Research progress of macrophage polarization in metabolic inflammation-related diseases
10.3760/cma.j.cn431274-20250217-00189
- VernacularTitle:巨噬细胞极化在代谢性炎症相关疾病中的研究进展
- Author:
Huiwen LING
1
;
Xiaoqing CHEN
;
Xumeng CHEN
Author Information
1. 湖南中医药大学湘杏学院，长沙 410208
- Publication Type:Journal Article
- Keywords:
Metabolic inflammation;
Macrophage polarization;
Type 2 diabetes;
Obesity;
Atherosclerosis;
Chronic liver disease
- From:
Journal of Chinese Physician
2025;27(11):1752-1756
- CountryChina
- Language:Chinese
-
Abstract:
As key cells of innate immunity, macrophages play a crucial role in maintaining immune homeostasis through their M1/M2 polarization states. Various metabolic diseases such as type 2 diabetes mellitus and obesity are closely associated with inflammation, and macrophage polarization imbalance is commonly observed during their progression. Regulating M1/M2 macrophage polarization is highly likely to become a potential therapeutic direction for metabolic inflammation-related diseases. Through literature research, this article summarizes the origin, activation, and polarization mechanisms of macrophages, and reviews the latest research progress on the imbalance and regulation of macrophage polarization in metabolic inflammation-related diseases. It aims to provide a theoretical basis for in-depth exploration of the molecular mechanisms and precise targets of macrophage polarization, as well as optimized strategies for the prevention and treatment of metabolic inflammation-related diseases.
