Predictive value of triglyceride-glucose index combined with LDL-C for major adverse cardiovascular events in patients with coronary heart disease complicated by type 2 diabetes mellitus
10.3760/cma.j.cn431274-20241031-01639
- VernacularTitle:TyG指数联合LDL-C对冠心病合并2型糖尿病患者发生主要不良心血管事件的预测价值
- Author:
Wulamu ADILA
1
;
Adi DILARE
1
;
Xiaolei LI
1
;
Keremu MUNAWAER
1
;
Yitong MA
1
;
Kulaixi AJIGULI
1
;
Kuerban ROUXIANGULI
1
;
Azhati ADILA
1
Author Information
1. 新疆医科大学第一附属医院心血管内科，乌鲁木齐 830054
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Diabetes mellitus, type 2;
Triglyceride;
Glucose;
Low-density lipoprotein cholesterol;
Major advent cardiovascular event
- From:
Journal of Chinese Physician
2025;27(11):1677-1682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of triglyceride-glucose (TyG) index combined with low-density lipoprotein cholesterol (LDL-C) for major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD) complicated by type 2 diabetes mellitus (T2DM).Methods:A total of 248 patients with CHD and T2DM admitted to the First Affiliated Hospital of Xinjiang Medical University from July 2022 to January 2024 were retrospectively enrolled. All patients were followed up for 2 years and divided into MACE group (43 cases) and non-MACE group (205 cases) according to the occurrence of MACE. Indicators such as TyG index and LDL-C were compared between the two groups, and their correlations with MACE were analyzed. Multivariate logistic regression was used to screen the risk factors for MACE in patients with CHD and T2DM. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of TyG index, LDL-C, and their combination for MACE in these patients.Results:Compared with the non-MACE group, the MACE group had significantly higher LDL-C [2.63(2.23, 2.95)mmol/L vs 1.99(1.60, 2.66)mmol/L, P<0.001] and TyG index [9.30(8.80, 9.87) vs 8.60(8.09, 9.15), P<0.001]. Multivariate logistic regression showed that TyG index was an independent risk factor for MACE in patients with CHD and T2DM ( OR=10.49, P<0.001). ROC curve results indicated that the area under the curve (AUC) of TyG index and LDL-C for predicting MACE were 0.731 and 0.686, respectively. The combined AUC of the two indicators for predicting MACE was 0.769(95% CI: 0.698-0.840), showing better predictive performance. Conclusions:TyG index combined with LDL-C has high predictive value for the risk of MACE in patients with CHD complicated by T2DM.
