Correlation between serum CA72-4 level and pathological differentiation degree of gastric cancer and its clinical significance
10.3760/cma.j.cn431274-20250831-01123
- VernacularTitle:血清CA72-4水平与胃癌病理分化程度的相关性及临床意义
- Author:
Xiao ZHANG
1
;
Yizhe DIAO
;
Tao DING
;
Weilang XU
;
Xiao QI
;
Peiqiang CHEN
;
Zhenyuan QIAN
;
Zaiyuan YE
Author Information
1. 浙江省人民医院（杭州医学院附属人民医院）胃肠病学重点实验室，杭州 310014
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Biomarkers, tumor;
CA72-4 antigen;
Tumor differentiation
- From:
Journal of Chinese Physician
2025;27(10):1451-1454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum carbohydrate antigen 72-4 (CA72-4) level and pathological differentiation degree of gastric cancer, and to provide reference for early diagnosis, prognosis evaluation and efficacy monitoring of gastric cancer.Methods:A retrospective study was conducted on 136 patients with gastric cancer admitted to Zhejiang Provincial People′s Hospital from April 2022 to December 2024. According to postoperative pathological diagnosis, patients were divided into well-differentiated group ( n=9), moderately differentiated group ( n=36) and poorly/undifferentiated group ( n=91). Preoperative CA72-4 levels and clinical characteristics of patients were collected to analyze the relationship between differentiation degree and CA72-4 level, and to compare the changes of CA72-4 before and after surgery in gastric cancer patients with different differentiation degrees. Results:The preoperative CA72-4 level in the poorly/undifferentiated group was significantly higher than that in the well-differentiated group and moderately differentiated group (all P<0.001). Preoperative CA72-4 level in gastric cancer patients was weakly negatively correlated with differentiation degree ( R=-0.341). After surgery, the CA72-4 level in the poorly/undifferentiated group decreased significantly compared with that before surgery ( P=0.043), while the changes in the well-differentiated group and moderately differentiated group were not significant. Conclusions:There are significant differences in CA72-4 levels among gastric cancer groups with different differentiation degrees. Preoperative CA72-4, as a tumor marker, is of great significance for early diagnosis, prognosis evaluation and postoperative monitoring of gastric cancer. Especially in patients with poorly/undifferentiated gastric cancer, the CA72-4 level is relatively high, which can be used for auxiliary diagnosis and formulation of treatment plans.
