Research progress on calcification mechanism and anti-calcification strategies of bovine pericardial bioprosthetic valve materials
10.3760/cma.j.cn431274-20250706-00894
- VernacularTitle:牛心包生物瓣膜材料钙化机制及抗钙化策略研究进展
- Author:
Hanwen ZHANG
1
;
Mingkui ZHANG
Author Information
1. 清华大学第一附属医院心脏中心，北京 100016
- Publication Type:Journal Article
- Keywords:
Cardiac valve replacement;
Bioprosthetic valve;
Anti-calcification;
Hyaluronic acid
- From:
Journal of Chinese Physician
2025;27(8):1153-1156
- CountryChina
- Language:Chinese
-
Abstract:
Calcification of bioprosthetic valve materials remains a major issue affecting the long-term survival of patients after heart valve replacement. The classic glutaraldehyde cross-linking technology has problems such as aldehyde toxicity, inflammatory response, and calcium salt deposition, which easily lead to valve calcification and deterioration. Moreover, the loss of glycosaminoglycan is also a cause of the deterioration of bioprosthetic valve materials. This article elaborates on the progress in the calcification mechanism of bioprosthetic valves and the 1, 4- Butanediol diglycidyl ether (BDDE) cross-linking technology in enhancing the enzyme resistance of hyaluronic acid and inhibiting the calcification process.
