Research progress on Noggin′s regulation of osteoporosis in signaling pathways

VernacularTitle:Noggin在信号通路中调节骨质疏松的研究进展
Author: Weiwen ZHAO ¹ ; Qinghao LIU ¹ ; Xuejun HE ¹ ; Zhiguo LUO ¹ ; Hao YIN ¹
Author Information

1. 湖南省人民医院（湖南师范大学附属第一医院）骨五科，长沙　410000
Publication Type:Journal Article
Keywords: Noggin; Bone morphogenetic protein; Wnt signaling pathway; Notch signaling pathway; Hedgehog signaling pathway
From: Journal of Chinese Physician 2025;27(6):948-952
CountryChina
Language:Chinese
Abstract: Noggin is a protein secreted by human cells and belongs to the bone morphogenetic protein (BMP) family, which can inhibit the formation and proliferation of bone tissue. The initial research found that Noggin is mainly involved in the development of the embryonic skeletal and nervous systems in vertebrate embryos. Subsequent studies have found that Noggin also plays an important role in bone metabolism and bone mineral density regulation in adults, mainly by regulating the activities of signaling pathways such as Wnt/β-catenin, notch and hedgehog. Meanwhile, there is also a certain mutual influence among various channels. This article mainly reviews the relevant research on the regulation of osteoporosis by Noggin in signaling pathways, clarifies the related mechanism of Noggin in various signaling pathways, and analyzes the current research status and prospects of Noggin.