Relationship and predictive value of serum ANXA1, MIP-1α, sTREM-1 with pulmonary infection in elderly patients with coronary heart disease combined with heart failure
10.3760/cma.j.cn431274-20231108-00531
- VernacularTitle:血清ANXA1、MIP-1α、sTREM-1与老年冠心病合并心力衰竭患者肺部感染的关系及其预测价值
- Author:
Zheng REN
1
;
Hongxin ZHU
1
;
Qiying JIN
1
;
Wenjing SU
1
;
Ying JIANG
1
Author Information
1. 秦皇岛市第二医院心内科，秦皇岛 066600
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Heart failure;
Annexin A1;
Macrophage inflammatory protein 1-α;
Soluble triggering receptor expressed on myeloid cells-1;
Pulmonary
- From:
Journal of Chinese Physician
2025;27(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum annexin A1 (ANXA1), macrophage inflammatory protein 1-α (MIP-1α), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pulmonary infection in elderly patients with coronary heart disease complicated with heart failure and their predictive value.Methods:A total of 197 elderly patients with coronary heart disease combined with heart failure admitted to the Second Hospital of Qinhuangdao from January 2021 to January 2023 were retrospectively selected, and divided into pulmonary infection group (36 cases) and non pulmonary infection group (161 cases) according to whether the patients had pulmonary infection during hospitalization. Serum ANXA1, MIP-1α and sTREM-1 levels were detected in two groups. Multivariate logistic regression model was used to analyze the influencing factors of lung infection in elderly patients with coronary heart disease combined with heart failure. The predictive value of serum ANXA1, MIP-1α and sTREM-1 levels on lung infection in elderly patients with coronary heart disease combined with heart failure was analyzed by receiver operating characteristic (ROC) curve.Results:The incidence of pulmonary infection in 197 elderly patients with coronary heart disease combined with heart failure was 18.27%(36/197). Compared with the non pulmonary infection group, the pulmonary infection group had higher levels of serum ANXA1, MIP-1 α, sTREM-1, C-reactive protein, procalcitonin, and higher proportion of New York Heart Association (NYHA) heart function grade Ⅳ and diabetes, and lower left ventricular ejection fraction (all P<0.05). Multivariate logistic regression analysis showed that NYHA cardiac function grade Ⅳ, diabetes mellitus and elevated levels of procalcitonin, ANXA1, MIP-1α and sTREM-1 were independent risk factors for pulmonary infection in elderly patients with coronary heart disease combined with heart failure (all P<0.05). ROC curve analysis showed that the area under the curve predicted by serum ANXA1, MIP-1α and sTREM-1 combined was 0.909, which was larger than that predicted by serum ANXA1, MIP-1α and sTREM-1 alone. Conclusions:Elevated levels of serum ANXA1, MIP-1α and sTREM-1 are independent risk factors for pulmonary infection in elderly patients with coronary heart disease combined with heart failure, and can be used as auxiliary predictors of pulmonary infection in elderly patients with coronary heart disease combined with heart failure.
