Advances in molecular mechanisms of protease-activated receptor 2 in inflammation associated with gastroesophageal reflux disease
10.3760/cma.j.cn431274-20231018-00403
- VernacularTitle:蛋白酶激活受体2在胃食管反流病相关炎症反应中的分子机制研究进展
- Author:
Yakufu SULAYIMAN
1
;
Yiliang LI
;
Aili AIKEBAIER
;
Abudureyimu KELIMU
Author Information
1. 新疆维吾尔自治区人民医院微创疝和腹壁外科，乌鲁木齐 830002
- Publication Type:Journal Article
- Keywords:
Receptors, proteinase-activated;
Receptor, PAR-2;
Gastroesophageal reflux
- From:
Journal of Chinese Physician
2024;26(12):1911-1915
- CountryChina
- Language:Chinese
-
Abstract:
Protease activating receptor (PAR) is a member of G protein-coupled receptor family, which includes four subtypes, namely PAR1, PAR2, PAR3 and PAR4. Except PAR2 trypsin receptor, other subunits belong to thrombin receptor. These receptors exist widely in various tissues of the body, especially in the digestive system to play a certain biological effect. In recent ten years, studies have shown that PAR1 and PAR2 play a key role in immune inflammatory response, which has aroused people′s attention. At present, it is of clinical value to study the development of gastroesophageal reflux disease (GERD) by exploring the unique activation mode of PAR2 in the pathological processes of esophageal mucosal damage, pain transmission, immune inflammatory response, stress and so on. This review aims to elucidate the molecular mechanism of PAR2 in gastroesophageal inflammation.
