The prognostic value of HALP index for overall survival after radical resection of distal cholangiocarcinoma
10.3760/cma.j.cn113855-20250112-00023
- VernacularTitle:HALP指数对远端胆管癌根治术后总生存期的预测价值
- Author:
Feng XU
1
;
Youwei MA
;
Jincan HUANG
;
Hanxuan WANG
;
Shaocheng LYU
;
Qiang HE
Author Information
1. 北京城市学院生物医药学部，北京 100094
- Publication Type:Journal Article
- Keywords:
Biliary tract neoplasms;
Prognosis;
HALP score
- From:
Chinese Journal of General Surgery
2025;40(7):533-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of HALP index on postoperative survival of patients with distal cholangiocarcinoma.Methods:A retrospective analysis was performed on 165 patients with distal cholangiocarcinoma who underwent surgery at Beijing Chaoyang Hospital, Capital Medical University from Jan 2011 to Dec 2022. Hemoglobin, albumin, lymphocyte count, and platelet count were recorded within one week before surgery, and hemoglobin×albumin×lymphocyte count/platelet count (HALP) was calculated. The receiver operating characteristic curve was drawn to determine the optimal cutoff value for predicting postoperative survival. According to the cutoff value, the patients were divided into high HALP group and low HALP group, and the prognosis of different groups was compared. Multivariate COX regression analysis was used to construct a prediction model for variables with statistically significant differences.Results:The median overall survival (OS) for the entire cohort was 29 months, with cumulative 1-, 3-, and 5-year survival rates of 78.2%, 38.8%, and 30.4%, respectively. The low-HALP group (median OS: 22 months) had significantly inferior survival compared to the high-HALP group (median OS: 37 months), with 1-, 3-, and 5-year survival rates of 70.1%,31.4%,22.8% vs. 89.7%,45.3%,38.1% ( χ2=7.695, P=0.006). Conclusion:The HALP index calculated from the patient's preoperative indicators can be used to predict the overall survival of patients with distal cholangiocarcinoma.
