Molecular mechanisms of obesity-related metabolic disorders in the development and progression of endometrial cancer and treatment of bariatric surgery
10.3760/cma.j.cn113855-20250307-00124
- VernacularTitle:肥胖症相关代谢紊乱在子宫内膜癌发生发展中的分子机制及减重手术的治疗效果
- Author:
Yijiao HE
1
;
Jianliu WANG
;
Zhaohui ZHONG
Author Information
1. 北京大学人民医院妇产科，北京 100044
- Publication Type:Journal Article
- Keywords:
Obesity, morbid;
Cancer, endometroid;
Gastrectomy;
Metabolic syndrome
- From:
Chinese Journal of General Surgery
2025;40(4):246-251
- CountryChina
- Language:Chinese
-
Abstract:
This article elaborates in detail on the mechanisms of action of obesity-related metabolic disorders in the occurrence and development of endometrial cancer. It also reviews the potential interventional targets and clinical bariatric surgeries, aiming to provide new theoretical basis and research directions for the prevention, diagnosis, and treatment of endometrial cancer. Through a comprehensive analysis of relevant literatures, it reveals the impacts of a series of metabolic changes induced by obesity, such as hormonal metabolic imbalance, inflammatory response, insulin resistance, et al on endometrial cancer. Meanwhile, it explores the potential interventional targets and corresponding clinical treatment strategies for these mechanisms.
