Recent advance in optogenetics in revealing mechanism of temporal lobe epilepsy
10.3760/cma.j.cn115354-20250313-00135
- VernacularTitle:光遗传学技术在颞叶癫痫机制揭示中的研究进展
- Author:
Ruting FU
1
;
Liya FANG
;
Yuanyuan LIU
;
Jiahao LIU
;
Yeyan WANG
;
Deming KONG
;
Jiawei LI
;
Jin GUO
Author Information
1. 佳木斯大学康复医学院，佳木斯 154007
- Publication Type:Journal Article
- Keywords:
Temporal lobe epilepsy;
Optogenetics;
Pathogenesis;
Neural circuit;
Light-sensitive protein;
Hippocampus;
Medial septal nucleus;
Cerebellum
- From:
Chinese Journal of Neuromedicine
2025;24(8):845-850
- CountryChina
- Language:Chinese
-
Abstract:
Research shows that epileptic seizures are essentially due to abnormal functions of neural circuits. Optogenetics regulates neural circuits by specifically expressing light-sensitive proteins in target neurons, which has now become an important tool in the research of temporal lobe epilepsy. Studies have shown that optogenetics focuses on brain regions such as the hippocampus, medial septal nucleus, cerebellum, and basal ganglia in studying temporal lobe epilepsy. This article reviews the research progress of optogenetics in exploring the pathogenesis and therapeutic targets of temporal lobe epilepsy, aiming to provide new ideas for temporal lobe epilepsy treatment.
